Posted by: Viktor Mar | 2010 February 26

Genome-scale map of 26 cancers is created

BOSTON (UPI) — U.S.-led scientists say they’ve created a genome-scale map of 26 cancers, revealing 100 genomic sites where DNA segments are missing or duplicated in tumors.
The international team of researchers said their study — the largest of its kind — uncovered novel cancer genes and genetic abnormalities shared across cancers. The scientists said their study also determined most of the genetic abnormalities are not unique to one form of cancer, but are shared across multiple cancers.
"Our findings show that many genome alterations are universal across different cancers," said Professor Matthew Meyerson of the Dana-Farber Cancer Institute and a member of the Broad Institute of Harvard University and the Massachusetts Institute of Technology. He said the findings suggest "in the future, a driving force behind cancer treatment will be common genomic alternations, rather than tumors’ tissue of origin," Myerson said.
The scientists said they collected more than 2,500 cancer specimens representing 26 cancer types, including lung, prostate, breast, ovarian, colon, esophageal, liver, brain and blood cancers.
The study is detailed in the journal Nature.

Copyright 2010 by United Press International



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